Preferred Label : Interleukin-1 Alpha;
NCIt synonyms : Interleukin 1, Alpha; IL1A; IL-1alpha; Preinterleukin 1 Alpha; IL1A Protein; IL-1A; Hematopoietin-1; IL1-Alpha; IL1; IL-1-a; Interleukin 1-Alpha; IL1F1; IL-1 Alpha; Pro-Interleukin-1-Alpha; Interleukin-1-Alpha;
NCIt related terms : IL-1-alpha;
NCIt definition : Interleukin-1 alpha (271 aa, 31 kDa) is encoded by the human IL1A gene. This protein
is involved in B-cell maturation and proliferation, thymocyte proliferation and the
stimulation of inflammation.;
Alternative definition : NCI-GLOSS: One of a group of related proteins made by leukocytes (white blood cells)
and other cells in the body. IL-1-alpha, one form of IL-1, is made mainly by one type
of white blood cell, the macrophage, and helps another type of white blood cell, the
lymphocyte, fight infections. It also helps leukocytes pass through blood vessel walls
to sites of infection and causes fever by affecting areas of the brain that control
body temperature. The other form of IL-1, IL-1-beta, acts the same as IL-1-alpha.
IL-1-alpha made in the laboratory is used as a biological response modifier to boost
the immune system in cancer therapy. IL-1-alpha is a type of cytokine.;
Codes from synonyms : CDR0000522475; CDR0000044044;
Origin ID : C20521;
UMLS CUI : C1702299;
Automatic exact mappings (from CISMeF team)
- OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- endogenous_product_related_to
- gene_encodes_gene_product
- gene_product_has_associated_anatomy
- gene_product_has_chemical_classification
- gene_product_has_organism_source
- gene_product_is_element_in_pathway
- gene_product_plays_role_in_biological_process
- is_target
