Complement C3d

Preferred Label : Complement C3d;

NCIt synonyms : C3d; Complement C3d Fragment;

NCIt definition : Complement C3d (302 aa, 34 kDa) is encoded by the human C3 gene. This protein is involved in the promotion of B-cell and complement activation.;

Alternative definition : CDISC: An antigen of the cleaved d fragment of the C3 complement protein. It can be considered as an autoantigen and is commonly associated with the autoimmune disease systemic lupus erythematosus.;

NCIt note : C3d is comprised of amino acids 1002-1303 of the complement C3 protein and is produced through proteolysis of C3 into an alpha chain (C3a) and a beta chain (C3b) followed by further proteolysis and inactivation of C3b. (UniProt);

NCI Metathesaurus CUI : CL556514;

Details

Origin ID

C154099;

UMLS CUI

C5441739;

Automatic exact mappings (from CISMeF team)
- Complement C3d [LOINC component]
- Complement component 3 [OMIM gene]
- Complement component 3 deficiency, autosomal recessive [OMIM Phenotype]
- complement C3d [MeSH concept]
- complement C3d [MeSH Descriptor]
OMIM relation
- Complement component 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- Complement C3d [LOINC component]
- Complement component C3d (substance) [SNOMED CT concept]
- complement C3d [MeSH Descriptor]
- complement C3d [MeSH concept]
- complement component c3d [SNOMED Notion]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- C3 Gene [NCIt concept]
- Complement Component Gene [NCIt concept]
gene_product_has_biochemical_function
- Complement [NCIt concept]
- Protein Fragment [NCIt concept]
gene_product_is_element_in_pathway
- Alternative Complement Pathway [NCIt concept]
- Classical Complement Pathway [NCIt concept]
- Complement Pathway [NCIt concept]
- Lectin Induced Complement Pathway [NCIt concept]
- Local Acute Inflammatory Response Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- B-Cell Activation [NCIt concept]
- Complement Activation [NCIt concept]
- Host Defense Mechanism [NCIt concept]

Keyword's position in hierarchy(ies) :

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