B-Cell Activation

Preferred Label : B-Cell Activation;

NCIt definition : A set of events occurring in B lymphocytes following stimulation with cognate antigen. Crosslinking the B cell antigen receptor (surface immunoglobulin) leads to increased expression of MHC class II molecules, exit from the resting state (G0) into the G1 phase of the cell cycle, and in the case of a strong antigenic stimulus, proliferation.;

Details

Origin ID

C19255;

UMLS CUI

C1155003;

Currated CISMeF NLP mapping
- B cell activation [GO term]
False automatic mappings
- B cell linker [ORDO Gene]
- B cell linker [HGNC gene]
Semantic type(s)
- Cell Function [UMLS semantic type]
UMLS correspondences (same concept)
- B cell activation [GO term]
biological_process_has_associated_location
- B-Lymphocyte [NCIt concept]
biological_process_has_initiator_chemical_or_drug
- Antigen [NCIt concept]
biological_process_has_result_biological_process
- B Cell Proliferation [NCIt concept]
biological_process_involves_gene_product
- Apoptosis Regulator Bcl-2 [NCIt concept]
- B-Lymphocyte Antigen CD19 [NCIt concept]
- Complement C3d [NCIt concept]
- Glucose-6-Phosphate Isomerase [NCIt concept]
- Immunoglobulin Lambda-Like Polypeptide 1 [NCIt concept]
- Immunoglobulin-Binding Protein 1 [NCIt concept]
- Low Affinity Immunoglobulin Gamma Fc Region Receptor II-B [NCIt concept]
- Paired Box Protein Pax-5 [NCIt concept]
- SH2B Adapter Protein 2 [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 5 [NCIt concept]
- Tyrosine-Protein Kinase Blk [NCIt concept]
- Tyrosine-Protein Kinase Lck [NCIt concept]
- Tyrosine-Protein Kinase SYK [NCIt concept]
biological_process_is_part_of_process
- Humoral Immunity [NCIt concept]
- Immune Response Process [NCIt concept]
is_physiologic_effect_of_chemical_or_drug
- Binetrakin [NCIt concept]
- Darbepoetin Alfa [NCIt concept]
- Efepoetin Alfa [NCIt concept]
- Epoetin Alfa [NCIt concept]
- Epoetin Beta [NCIt concept]
- Epoetin Delta [NCIt concept]
- Epoetin Zeta [NCIt concept]
- Idestopoetin Alfa [NCIt concept]
- Pegdarbepoetin Beta [NCIt concept]
- Peginesatide Acetate [NCIt concept]
- Pegol-sihematide Injection [NCIt concept]
- Pegzerepoetin Alfa [NCIt concept]
- Recombinant Erythropoietin [NCIt concept]
process_involves_gene
- BCL2 Gene [NCIt concept]
- BCL2 wt Allele [NCIt concept]
- BLK Gene [NCIt concept]
- BLK wt Allele [NCIt concept]
- CD19 Gene [NCIt concept]
- CD19 wt Allele [NCIt concept]
- CD40LG Gene [NCIt concept]
- CD40LG wt Allele [NCIt concept]
- CXCL13 Gene [NCIt concept]
- CXCL13 wt Allele [NCIt concept]
- FCGR2B Gene [NCIt concept]
- FCGR2B wt Allele [NCIt concept]
- FIBP Gene [NCIt concept]
- FIBP wt Allele [NCIt concept]
- GPI Gene [NCIt concept]
- GPI wt Allele [NCIt concept]
- IGBP1 Gene [NCIt concept]
- IGBP1 wt Allele [NCIt concept]
- IGLL1 Gene [NCIt concept]
- IGLL1 wt Allele [NCIt concept]
- LCK Gene [NCIt concept]
- LCK wt Allele [NCIt concept]
- PAX5 Gene [NCIt concept]
- PAX5 wt Allele [NCIt concept]
- RGS1 Gene [NCIt concept]
- RGS1 wt Allele [NCIt concept]
- SH2B2 Gene [NCIt concept]
- SH2B2 wt Allele [NCIt concept]
- SH2D1A Gene [NCIt concept]
- SH2D1A wt Allele [NCIt concept]
- SYK Gene [NCIt concept]
- SYK wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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