SH2B Adapter Protein 2

Preferred Label : SH2B Adapter Protein 2;

NCIt synonyms : Adaptor Protein Containing PH and SH2 Domains; Adaptor Protein with Pleckstrin Homology and SRC Homology 2 Domains; APS; Adapter Protein with Pleckstrin Homology and SRC Homology 2 Domains; APS Protein; SH2 And PH Domain-Containing Adapter Protein APS;

NCIt definition : SH2B adaptor protein 2 (632 aa, 68 kDa) is encoded by the human SH2B2 gene. This protein is involved in the modulation of receptor tyrosine kinase signaling pathways.;

Details

Origin ID

C21323;

UMLS CUI

C1449108;

Automatic exact mappings (from CISMeF team)
- Autoimmune polyendocrine syndrome, type I, with or without reversible metaphyseal dysplasia [OMIM Phenotype]
- Autoimmune polyendocrine syndrome, type II [OMIM Phenotype]
- Autoimmune polyendocrinopathy [ORDO Disease]
- Autoimmune polyendocrinopathy (disorder) [SNOMED CT concept]
- Kallikrein-related peptidase 3 [OMIM gene]
- Pathology diagnosis (contextual qualifier) (qualifier value) [SNOMED CT concept]
- Peeling skin syndrome 2 [OMIM Phenotype]
- Sh2b adaptor protein 2 [OMIM gene]
- anterior parolfactory sulcus [UBERON concept]
- surgical flaps [MeSH Descriptor]
False automatic mappings
- Antiphospholipid syndrome [ORDO Disease]
- Musical perfect pitch [OMIM Phenotype]
OMIM relation
- Sh2b adaptor protein 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- SH2B2 protein, human [MeSH concept]
- SH2B2 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Adaptor Signaling Protein Gene [NCIt concept]
- SH2B2 Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_expressed_in_tissue
- Leukocyte [NCIt concept]
- Prostate Gland [NCIt concept]
- Small Intestine [NCIt concept]
- Spleen [NCIt concept]
- Striated Muscle Tissue [NCIt concept]
- Testis [NCIt concept]
- Uterus [NCIt concept]
gene_product_has_structural_domain_or_motif
- PH Domain [NCIt concept]
- SH2 Domain [NCIt concept]
- Tyrosine Phosphorylation Site [NCIt concept]
gene_product_is_element_in_pathway
- Insulin/Insulin Receptor Signaling Pathway [NCIt concept]
- Neurotrophin Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- B-Cell Activation [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]

Keyword's position in hierarchy(ies) :

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