NCIt definition : A recombinant therapeutic agent that is chemically identical to or similar to the
endogenous cytokine human erythropoietin (EPO). Produced primarily by cells of the
peritubular capillary endothelium of the kidney in response to hypoxia, circulating
EPO binds to EPO receptors on the surface of committed erythroid progenitors in the
bone marrow resulting in their replication and maturation into functional erythrocytes.;
Alternative definition : NCI-GLOSS: A substance that is made in the laboratory and stimulates the bone marrow
to make red blood cells. It is a type of antianemic and a type of recombinant human
erythropoietin.;