Tyrosine-Protein Kinase SYK

Preferred Label : Tyrosine-Protein Kinase SYK;

NCIt synonyms : PTK72 Protein; SYK; 2.7.1.112; PTK72; Spleen Tyrosine Kinase; EC 2.7.10.2; p72-Syk; Protein-Tyrosine Kinase SYK;

NCIt definition : Tyrosine-protein kinase SYK (635 aa, 72 kDa) is encoded by the human SYK gene. This protein plays a role in tyrosine phosphorylation, receptor signaling and B- and T-cell differentiation.;

Détails

Origin ID

C18169;

UMLS CUI

C0134982;

OMIM relation
- Protein-tyrosine kinase syk [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- SYK protein, human [MeSH Supplementary Concept]
- SYK protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Pediatric Oncology Target Cell Lineage Determinant Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Kinase Family Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- SYK Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- SH2 Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
- Tyrosine Kinase Domain [NCIt concept]
gene_product_is_element_in_pathway
- Alpha-Synuclein Signaling Pathway [NCIt concept]
- Aspirin Inhibition of Platelet Activation Pathway [NCIt concept]
- Atypical NF-kappaB Signaling Pathway [NCIt concept]
- B Cell Receptor Signaling Pathway [NCIt concept]
- BCR Immune Response Signaling Pathway [NCIt concept]
- BCR Signaling Pathway [NCIt concept]
- FAS Signaling Pathway PID [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway BioCarta [NCIt concept]
- Fc Epsilon Receptor I Signaling Pathway KEGG [NCIt concept]
- Fc Gamma Receptor-Mediated Phagocytosis Pathway [NCIt concept]
- Fc-Epsilon Receptor I Signaling Pathway PID [NCIt concept]
- IL2 Signaling Pathway [NCIt concept]
- IL2RB Pathway [NCIt concept]
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- Osteopontin-Mediated Signaling Pathway [NCIt concept]
- Ras-Independent Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- Thromboxane A2 Receptor Family Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- B-Cell Activation [NCIt concept]
- Calcium Signaling [NCIt concept]
- Cell Differentiation Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Proliferation [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Signal Transduction [NCIt concept]
- Tyrosine Phosphorylation [NCIt concept]
is_target
- Cerdulatinib [NCIt concept]
- Cevidoplenib [NCIt concept]
- Cevidoplenib Dimesylate [NCIt concept]
- Entospletinib [NCIt concept]
- Fostamatinib [NCIt concept]
- Fostamatinib Disodium [NCIt concept]
- Mivavotinib [NCIt concept]
- Mivavotinib Citrate [NCIt concept]

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