Preferred Label : Entospletinib;
NCIt synonyms : 6-(1H-Indazol-6-yl)-N-(4-(morpholin-4-yl)phenyl)imidazo(1,2-a)pyrazin-8-amine; ENTO; Imidazo(1,2-a)pyrazin-8-amine, 6-(1H-indazol-6-yl)-N-(4-(4-morpholinyl)phenyl)-;
NCIt definition : An orally available inhibitor of spleen tyrosine kinase (Syk), with potential antineoplastic
activity. Upon oral administration of entospletinib, this agent may inhibit the activity
of Syk, which inhibits B-cell receptor (BCR) signaling and leads to an inhibition
of tumor cell activation, migration, adhesion and proliferation. Syk, a non-receptor
cytoplasmic, BCR-associated tyrosine kinase, is expressed in hematopoietic tissues
and is often overexpressed in hematopoeitic malignancies.;
UNII : 6I3O3W6O3B;
InChIKey : XSMSNFMDVXXHGJ-UHFFFAOYSA-N;
CAS number : 1229208-44-9;
Molecule name : GS-9973; GS 9973;
Codes from synonyms : 187;
Origin ID : C105402;
UMLS CUI : C4053696;
Currated CISMeF NLP mapping
- Semantic type(s)
- concept_is_in_subset
- has_target
