Preferred Label : Mivavotinib;
NCIt synonyms : syk-Inhibitor TAK-659; syk Inhibitor TAK659; syk Inhibitor TAK-659; syk-Inhibitor TAK659; Spleen Tyrosine Kinase Inhibitor TAK659; 3H-Pyrrolo(3,4-C)pyridin-3-one, 6-(((1R,2S)-2-aminocyclohexyl)amino)-7-fluoro-1,2-dihydro-4-(1-methyl-1H-pyrazol-4-yl)-; TAK659 Free Base; TAK-659 Free Base;
NCIt definition : An inhibitor of spleen tyrosine kinase (syk), with potential anti-inflammatory, immunomodulating,
and antineoplastic activities. Upon administration, mivavotinib may inhibit the activity
of syk, which abrogates downstream B-cell receptor (BCR) signaling and leads to an
inhibition of B-cell activation, chemotaxis, adhesion and proliferation. Syk, a BCR-associated
non-receptor tyrosine kinase that mediates diverse cellular responses, including proliferation,
differentiation, and phagocytosis, is expressed in hematopoietic tissues and is often
overexpressed in hematopoietic malignancies.;
UNII : 8QR88H79VX;
InChIKey : MJHOMTRKVMKCNE-NWDGAFQWSA-N;
CAS number : 1312691-33-0;
NCI Metathesaurus CUI : CL455236;
Origin ID : C113162;
UMLS CUI : C5235371;
Semantic type(s)
- UMLS correspondences (same concept)
- TAK-659 [MeSH Supplementary Concept]
- concept_is_in_subset
- has_salt_form
- has_target
- is_free_acid_or_base_form_of
