" /> Mivavotinib - CISMeF





Preferred Label : Mivavotinib;

NCIt synonyms : syk-Inhibitor TAK-659; syk Inhibitor TAK659; syk Inhibitor TAK-659; syk-Inhibitor TAK659; Spleen Tyrosine Kinase Inhibitor TAK659; 3H-Pyrrolo(3,4-C)pyridin-3-one, 6-(((1R,2S)-2-aminocyclohexyl)amino)-7-fluoro-1,2-dihydro-4-(1-methyl-1H-pyrazol-4-yl)-; TAK659 Free Base; TAK-659 Free Base;

NCIt definition : An inhibitor of spleen tyrosine kinase (syk), with potential anti-inflammatory, immunomodulating, and antineoplastic activities. Upon administration, mivavotinib may inhibit the activity of syk, which abrogates downstream B-cell receptor (BCR) signaling and leads to an inhibition of B-cell activation, chemotaxis, adhesion and proliferation. Syk, a BCR-associated non-receptor tyrosine kinase that mediates diverse cellular responses, including proliferation, differentiation, and phagocytosis, is expressed in hematopoietic tissues and is often overexpressed in hematopoietic malignancies.;

UNII : 8QR88H79VX;

InChIKey : MJHOMTRKVMKCNE-NWDGAFQWSA-N;

CAS number : 1312691-33-0;

NCI Metathesaurus CUI : CL455236;

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03/07/2025


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