Preferred Label : Mivavotinib Citrate;
NCIt synonyms : 6-(((1R,2S)-2-Aminocyclohexyl)Amino)-7-Fluoro-1,2-Dihydro-4-(1-Methyl-1H-Pyrazol-4-yl)-3H-Pyrrolo(3,4-C)Pyridin-3-One,
2-Hydroxypropane-1,2,3-Tricarboxylate (1:1);
NCIt definition : An inhibitor of spleen tyrosine kinase (syk), with potential anti-inflammatory, immunomodulating,
and antineoplastic activities. Upon administration, mivavotinib may inhibit the activity
of syk, which abrogates downstream B-cell receptor (BCR) signaling and leads to an
inhibition of B-cell activation, chemotaxis, adhesion and proliferation. Syk, a BCR-associated
non-receptor tyrosine kinase that mediates diverse cellular responses, including proliferation,
differentiation, and phagocytosis, is expressed in hematopoietic tissues and is often
overexpressed in hematopoietic malignancies.;
UNII : 6ZJ8V3Q0H1;
CAS number : 1952251-25-0;
Molecule name : TAK-659;
NCI Metathesaurus CUI : CL1793040;
Origin ID : C188286;
UMLS CUI : C5706584;
Semantic type(s)
- concept_is_in_subset
- has_target
