Preferred Label : Fostamatinib;
NCIt synonyms : 2H-Pyrido(3,2-B)-1,4-Oxazin-3(4H)-One, 6-((5-Fluoro-2-((3,4,5-Trimethoxyphenyl)Amino)-4-Pyrimidinyl)Amino)-2,2-Dimethyl-4-((Phosphonooxy)Methyl)-; (6-((5-Fluoro-2-((3,4,5-Trimethoxyphenyl)Amino)Pyrimidin-4-yl)Amino)-2,2-Dimethyl-3-Oxo-2,3-Dihydro-4H-Pyrido(3,2-B)(1,4)Oxazin-4-Yl)Methyl
Dihydrogen Phosphate; R788 Free Acid; R-788 Free Acid; R 788 Free Acid; R-935788 Free Acid; R 935788 Free Acid;
NCIt definition : A small molecule Syk kinase inhibitor with potential anti-inflammatory and immunomodulating
activities. Fostamatinib inhibits Syk kinase-mediated IgG Fc gamma receptor signaling,
resulting in inhibition of the activation of mast cells, macrophages, and B-cells
and related inflammatory responses and tissue damage. Syk kinase, widely expressed
in hematopoietic cells, is a nonreceptor tyrosine kinase that is involved in coupling
activated immunoreceptors to signal downstream events that mediate diverse cellular
responses, including proliferation, differentiation, and phagocytosis.;
UNII : SQ8A3S5101;
InChIKey : GKDRMWXFWHEQQT-UHFFFAOYSA-N;
CAS number : 901119-35-5;
Chemical formula : C23H26FN6O9P;
Codes from synonyms : 234;
Origin ID : C95222;
UMLS CUI : C2713632;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_salt_form
- has_target
- is_free_acid_or_base_form_of
