Preferred Label : Fostamatinib Disodium;
NCIt synonyms : R-935788 Sodium; SYK Kinase Inhibitor R-935788; 2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one, 6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-
4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-, Disodium Salt, Hexahydrate; Fostamatinib Disodium Hexahydrate; R935788 Sodium;
NCIt related terms : R788 sodium;
NCIt definition : An orally available disodium salt of the Syk kinase inhibitor fostamatinib with potential
anti-inflammatory and immunomodulating activities. Fostamatinib inhibits Syk kinase-mediated
IgG Fc gamma receptor signaling, resulting in inhibition of the activation of mast
cells, macrophages, and B-cells and related inflammatory responses and tissue damage.
Syk kinase, widely expressed in hematopoietic cells, is a nonreceptor tyrosine kinase
that is involved in coupling activated immunoreceptors to signal downstream events
that mediate diverse cellular responses, including proliferation, differentiation,
and phagocytosis.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer and certain other
diseases, such as rheumatoid arthritis. It may block tumor cell signaling and growth.
It is a type of tyrosine kinase inhibitor.;
UNII : 86EEZ49YVB;
InChIKey : ZQGJCHHKJNSPMS-UHFFFAOYSA-L;
CAS number : 914295-16-2;
Drug name : Tavalisse;
Chemical formula : C23H24FN6O9P.2Na.6H2O;
NCI Metathesaurus CUI : CL375266;
Codes from synonyms : CDR0000648596; CDR0000648595;
Origin ID : C69128;
UMLS CUI : C2608107;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- concept_is_in_subset
- has_free_acid_or_base_form
- has_target
- is_salt_form_of
