" /> Tumor Necrosis Factor Receptor Superfamily Member 5 - CISMeF





Preferred Label : Tumor Necrosis Factor Receptor Superfamily Member 5;

NCIt synonyms : B Cell-Associated Molecule CD40; TNFRSF5; CD40 Type II Isoform; CD40 Antigen; CD40; Nerve Growth Factor Receptor-Related B-Lymphocyte Activation Molecule; CD40L Receptor; CDw40; B Cell Surface Antigen CD40;

NCIt definition : Tumor necrosis factor receptor superfamily member 5 (277 aa, 31 kDa) is encoded by the human CD40 gene. This protein is involved in the positive regulation of immunoglobulin secretion.;

NCIt note : Related to NGFR, TNFR-alpha, and CD27, CD40 is a 50 kD glycophosphoprotein homodimer expressed on mature B-cells, but not on plasma cells, that plays an important role in B-cell development and activation. These CD40 homologies imply that its ligand may be a soluble factor and that CD40 is a member of the cytokine receptor family. CD40/CD40-ligand interactions play a critical role in the activation of humoral and cell-mediated immune responses. CD40-dependent activation of B-cells is important for generation of memory B-cells within germinal centers. (OMIM);

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15/05/2024


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