Lucatumumab - CISMeF

Preferred Label : Lucatumumab;

NCIt synonyms : Monoclonal Antibody CHIR-12.12; Anti-CD40 Monoclonal Antibody CHIR-12.12; Monoclonal Antibody CHIR-12 12;

NCIt definition : A fully human monoclonal antibody directed against the B-cell surface antigen CD40 with potential antineoplastic activity. Lucatumumab binds to and inhibits CD40, thereby inhibiting CD40 ligand-induced cell proliferation and triggering cell lysis via antibody-dependent cellular cytotoxicity (ADCC) in cells overexpressing CD40. CD40, an integral membrane protein found on the surface of B lymphocytes, is a member of the tumor necrosis factor receptor superfamily and is highly expressed in a number of B-cell malignancies.;

UNII : P0EP9VFC4R;

CAS number : 903512-50-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 903512-50-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : HCD-122; CHIR-12.12;

Details

Origin ID

C48405;

UMLS CUI

C2980061;

Currated CISMeF NLP mapping
- lucatumumab [MeSH concept]
- lucatumumab [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- lucatumumab [MeSH Supplementary Concept]
- lucatumumab [MeSH concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Tumor Necrosis Factor Receptor Superfamily Member 5 [NCIt concept]

Keyword's position in hierarchy(ies) :

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