Preferred Label : CD40 Antigens;
MeSH definition : A member of the tumor necrosis factor receptor superfamily with specificity for CD40
LIGAND. It is found on mature B-LYMPHOCYTES and some EPITHELIAL CELLS, lymphoid DENDRITIC
CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for
generation of memory B-cells within the germinal centers. Mutations of the gene for
CD40 antigen result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the
receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.; Members of the tumor necrosis factor receptor superfamily with specificity for CD40
LIGAND. They are found on mature B-LYMPHOCYTES, some EPITHELIAL CELLS; and lymphoid
DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important
for generation of memory B-cells within the germinal centers. Mutations in the CD40
antigen gene result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the
receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.;
MeSH synonym : tumor necrosis factor receptor superfamily, member 5; antigen, cdw40; tnfrsf5 receptor; receptor, tnfrsf5; cd40 antigen; antigen, cd40; cdw40 antigen; Antigens, CD40;
Is substance : O;
Origin ID : D019013;
UMLS CUI : C0054959;
Allowable qualifiers
- Currated CISMeF NLP mapping
- Indexing information
- Record concept(s)
- See also
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
A member of the tumor necrosis factor receptor superfamily with specificity for CD40
LIGAND. It is found on mature B-LYMPHOCYTES and some EPITHELIAL CELLS, lymphoid DENDRITIC
CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for
generation of memory B-cells within the germinal centers. Mutations of the gene for
CD40 antigen result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the
receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Members of the tumor necrosis factor receptor superfamily with specificity for CD40
LIGAND. They are found on mature B-LYMPHOCYTES, some EPITHELIAL CELLS; and lymphoid
DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important
for generation of memory B-cells within the germinal centers. Mutations in the CD40
antigen gene result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the
receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=FR&Expert=101088
2011
France
scientific and technical information
hyper-IgM immunodeficiency syndrome
Hyper-IgM immunodeficiency syndrome, type 1
CD40 Antigens
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