NCIt synonyms : Autologous hCD40L-transduced CLL B Cell Vaccine;
NCIt definition : A cancer vaccine consisting of autologous, B-chronic lymphocytic leukemia (B-CLL)
cells harvested from a patient and transduced with an adenoviral vector encoding the
gene for the human CD40 ligand (CD40L; TRAP; CD154), with potential immunostimulating
and antineoplastic activities. Upon reintroduction into the patient, the autologous
CD40L-expressing B-CLL vaccine expresses the co-stimulatory molecule CD40L, which
binds to its cognate receptor, CD40, on antigen presenting cells (APC). This induces
apoptosis, stimulates maturation and proliferation of APCs, and facilitates a cytotoxic
T-lymphocyte (CTL) response against tumor cells. CD40L is a type II membrane protein
that binds to CD40, which is a cell surface receptor that belongs to the tumor necrosis
factor (TNF) receptor superfamily.;