Preferred Label : FAP/CD40-targeting Agent SHR-7367;
NCIt definition : An agent targeting both the tumor-associated antigen (TAA) fibroblast activation protein
(FAP) and CD40, with potential immunostimulatory and antineoplastic activities. Upon
administration, FAP/CD40-targeting agent SHR-7367 targets and binds to both FAP, localized
predominantly on cancer-associated fibroblasts (CAFs) in the tumor stroma, and CD40,
a cell surface stimulatory receptor expressed on various immune cells including B-lymphocytes,
monocytes and dendritic cells (DCs). The simultaneous binding to FAP and CD40 results
in local clustering of FAP-expressing tumor stromal cells and CD40-expressing immune
cells. Activation of CD40 induces proliferation and activation of B-lymphocytes, shifts
the induction of suppressive macrophages towards immunostimulatory macrophages, activates
monocyte-derived DCs (moDCs), and leads to the secretion of inflammatory cytokines,
which activates the immune system to induce the proliferation and activation of cytotoxic
T-lymphocytes (CTLs) against tumor cells. CD40, a member of the tumor necrosis factor
receptor superfamily (TNFRSF), plays a key role in the activation of the immune system.
FAP is abundantly expressed by CAFs in many solid tumors.;
Molecule name : SHR-7367; SHR 7367;
NCI Metathesaurus CUI : CL1907038;
Origin ID : C200202;
concept_is_in_subset
- has_target
