Bystander B Cell Activation Pathway

Preferred Label : Bystander B Cell Activation Pathway;

NCIt related terms : Bystander B Cell Activation;

Alternative definition : BIOCARTA: Expression of Fas-Ligand by T cells can induce apoptosis through interaction with Fas on the target cell. A target of Fas-mediated apoptosis is the B cell. B cells that are not activated by antigen, bystander B cells, can interact through CD40 with the CD40 ligand on T cells. The CD40-CD40L interaction induces Fas expression by bystander B cells, and the interaction of Fas with the T cell Fas-Ligand, followed by B cell apoptosis. B cells that are activated by antigen binding and that interact with the T cell receptor through the B cell MHC II appear to become resistant to Fas-mediated apoptosis, survive and proliferate. IL-4 also appears to confer B cell resistance to Fas-mediated apoptosis. The induction of apoptosis in non-antigen stimulated B cells may prevent B cells from proliferating inappropriately and failure of this mechanism may be involved in autoimmune disorders and B cell lymphomas. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_bbcellPathway;

Details

Origin ID

C39003;

UMLS CUI

C1511352;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- CD40 Ligand [NCIt concept]
- HLA Class II Histocompatibility Antigen, DQ Beta 1 Chain [NCIt concept]
- T-Cell Surface Glycoprotein CD4 [NCIt concept]
- T-Cell-Specific Surface Glycoprotein CD28 [NCIt concept]
- Tumor Necrosis Factor Ligand Superfamily Member 6 [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 5 [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 6 [NCIt concept]
pathway_has_gene_element
- CD28 wt Allele [NCIt concept]
- CD4 wt Allele [NCIt concept]
- CD40 wt Allele [NCIt concept]
- CD40LG wt Allele [NCIt concept]
- FAS wt Allele [NCIt concept]
- FASLG wt Allele [NCIt concept]
- HLA-DQB1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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