Tumor Necrosis Factor Receptor Superfamily Member 6

Preferred Label : Tumor Necrosis Factor Receptor Superfamily Member 6;

NCIt synonyms : Apoptosis Antigen 1; CD95 Antigen; FASLG Receptor; APO-1 Cell Surface Antigen; TNFRSF6; Apo-1 Antigen; Surface Antigen APO1; FAS Antigen; TNF Receptor Superfamily Member 6; Apoptosis-Mediating Surface Antigen FAS; FAS;

NCIt definition : Tumor necrosis factor receptor superfamily member 6 (335 aa, 38 kDa) is encoded by the human FAS gene. This protein is involved in the regulation of apoptosis.;

NCIt note : FAS differentiation antigen is expressed in the thymus, liver, ovary, and heart, and on a variety of cell lines including myeloid and lymphoblastoid cell lines. Its primary role is to regulate T-cell development in the thymus and to regulate peripheral immune responses, by triggering apoptosis. FAS is a member of the TNFR/NGFR superfamily. Activation of FAS by FAS ligand results in the formation of a death-inducing signaling complex with the signal adaptor protein FADD and with procaspase 8. This association generates CASP8, activating a cascade of caspases. (OMIM);

Details

Origin ID

C17776;

UMLS CUI

C1454645;

Currated CISMeF NLP mapping
- fas Receptor [MeSH Descriptor]
- fas Receptor [MeSH concept]
OMIM relation
- Fas cell surface death receptor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- FAS protein, human [MeSH concept]
- FAS protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Receptor Gene [NCIt concept]
- FAS Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- TNF Receptor Family Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Regulator [NCIt concept]
- Cell Surface Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Death Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Allograft Rejection Pathway [NCIt concept]
- Alzheimer's Disease Pathway KEGG [NCIt concept]
- Antigen Dependent B Cell Activation Pathway [NCIt concept]
- Apoptosis Pathway [NCIt concept]
- Autoimmune Thyroid Disease Pathway [NCIt concept]
- Bystander B Cell Activation Pathway [NCIt concept]
- CTL-mediated Immune Response Pathway [NCIt concept]
- Cell Cycle Progression Pathway [NCIt concept]
- Chagas Disease Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Fas Signaling Pathway BioCarta [NCIt concept]
- Graft-Versus-Host Disease Pathway [NCIt concept]
- HIV Induced T Cell Apoptosis Pathway [NCIt concept]
- HIV-I Nef in Apoptosis Pathway [NCIt concept]
- HSP27 Regulation Pathway [NCIt concept]
- IL2RB Pathway [NCIt concept]
- Keratinocyte Differentiation Pathway [NCIt concept]
- MAPK Signaling Pathway [NCIt concept]
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- PML Transcription Regulation Pathway [NCIt concept]
- Type I Diabetes Mellitus Pathway [NCIt concept]
- p53 Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Negative Regulation of Apoptosis [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tumor Necrosis Factor Signaling Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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