Cell Cycle Progression Pathway

Preferred Label : Cell Cycle Progression Pathway;

NCIt related terms : Regulation of cell cycle progression by Plk3;

Alternative definition : BIOCARTA: The focus of this pathway is to illustrate the role of Polo-like Kinase 3 (Plk3 also known as Prk and Fnk) as part of the regulatory cascade leading to apoptosis and the arrest cell cycle progression prior to M phase. Phosphorylation of Cdc25C on serine-216 causes the arrest of the cell cycle at the G2/M phase border by preventing Cdc25C from activating cyclinB1/Cdk1. Xie et al. demonstrated that Plk3, like Chk1 and Chk2, also phosphorylates Cdc25C on serine-216 contributing to cell cycle arrest. Additionally they found that Plk3 also phosphorylates p53 on serine 20, a step that is stimulatory in the process leading up to p53-mediated apoptosis. Wang Q et al. found that Plk3 is closely associated with the centrosome and that this is dependent on the integrity of the microtubules. Expression of constitutively active or defective Plk3 kinase had significant defects on the shape and nature of the microtubule apparatus of the cell. In either case cell cycle progression was halted and apoptosis occurred. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_plk3Pathway;

Details

Origin ID

C39195;

UMLS CUI

C1516335;

Semantic type(s)
- Cell Function [UMLS semantic type]
has_gene_product_element
- ATR-Interacting Protein [NCIt concept]
- CREB-Binding Protein [NCIt concept]
- Caspase-3 [NCIt concept]
- Caspase-6 [NCIt concept]
- Cellular Tumor Antigen p53 [NCIt concept]
- Death Domain-Associated Protein 6 [NCIt concept]
- GTPase HRas [NCIt concept]
- Retinoblastoma-Associated Protein [NCIt concept]
- Serine-Protein Kinase ATM [NCIt concept]
- Serine/Threonine-Protein Kinase ATR [NCIt concept]
- Serine/Threonine-Protein Kinase Chk1 [NCIt concept]
- Serine/Threonine-Protein Kinase Chk2 [NCIt concept]
- Serine/Threonine-Protein Kinase PLK3 [NCIt concept]
- Tumor Necrosis Factor [NCIt concept]
- Tumor Necrosis Factor Ligand Superfamily Member 6 [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 1A [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 6 [NCIt concept]
pathway_has_gene_element
- ATM wt Allele [NCIt concept]
- ATR wt Allele [NCIt concept]
- ATRIP wt Allele [NCIt concept]
- CASP3 wt Allele [NCIt concept]
- CASP6 wt Allele [NCIt concept]
- CHEK1 wt Allele [NCIt concept]
- CHEK2 wt Allele [NCIt concept]
- CREBBP wt Allele [NCIt concept]
- DAXX wt Allele [NCIt concept]
- FAS wt Allele [NCIt concept]
- FASLG wt Allele [NCIt concept]
- HRAS wt Allele [NCIt concept]
- PLK3 wt Allele [NCIt concept]
- RB1 wt Allele [NCIt concept]
- TNFRSF1A wt Allele [NCIt concept]
- TP53 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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