Serine/Threonine-Protein Kinase ATR

Preferred Label : Serine/Threonine-Protein Kinase ATR;

NCIt synonyms : Rad3 Related Protein; Protein Kinase ATR; FRAP-Related Protein-1; FRP1; ATR; Ataxia Telangiectasia and Rad3-Related Protein; FRAP-Related Protein 1; EC 2.7.11.1; Ataxia Telangiectasia and Rad3 Related Protein; Protein Kinase-ATR;

NCIt definition : Serine/threonine-protein kinase ATR (2644 aa, 301 kDa) is encoded by the human ATR gene. This protein plays a role in protein phosphorylation, DNA repair and cell cycle progression.;

NCIt note : Serine/threonine-protein kinase ATR contains 1 FAT domain, 1 FATC domain, 2 HEAT repeats and 1 PI3K/PI4K domain. (UniProt);

Details

Origin ID

C21430;

UMLS CUI

C3711837;

Currated CISMeF NLP mapping
- Serpin peptidase inhibitor, clade a, member 2, pseudogene [OMIM Phenotype]
OMIM relation
- Atr serine/threonine kinase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- ATR protein, human [MeSH concept]
- ATR protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ATR Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- BARD1 Signaling Pathway [NCIt concept]
- Cancer Susceptibility Pathway [NCIt concept]
- Cell Cycle Pathway [NCIt concept]
- Cell Cycle Progression Pathway [NCIt concept]
- Circadian Rhythm Pathway PID [NCIt concept]
- G1/S Checkpoint Pathway [NCIt concept]
- G2/M Checkpoint Pathway [NCIt concept]
- p53 Signaling Pathway KEGG [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Regulation Process [NCIt concept]
- DNA Recombination Process [NCIt concept]
- DNA Repair [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- ATR Inhibitor [NCIt concept]
- ATR Inhibitor ART0380 [NCIt concept]
- ATR Inhibitor ATG-018 [NCIt concept]
- ATR Inhibitor ATRN-119 [NCIt concept]
- ATR Inhibitor IMP9064 [NCIt concept]
- Berzosertib [NCIt concept]
- Camonsertib [NCIt concept]
- Ceralasertib [NCIt concept]
- Elimusertib [NCIt concept]
- Gartisertib [NCIt concept]
- Tuvusertib [NCIt concept]

Keyword's position in hierarchy(ies) :

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