PLK3 wt Allele

Preferred Label : PLK3 wt Allele;

NCIt synonyms : Polo-Like Kinase 3 (Drosophila) wt Allele; Cytokine-Inducible Kinase Gene; CNK; FNK; PRK; CNK wt Allele;

NCIt definition : Human PLK3 wild-type allele is located in the vicinity of 1p34.1 and is approximately 6 kb in length. This allele, which encodes serine/threonine-protein kinase PLK3 protein, plays a role in the regulation of M phase functions during the cell cycle. The PLK3 gene is down-regulated in certain types of cancer (head and neck squamous cell carcinomas, lung carcinomas) and overexpressed in other types of cancer (breast carcinomas and highly-proliferating malignant epithelial ovarian tumors).;

NCIt note : The PLK3 gene is putatively involved in regulation of cell cycle progression and tumorigenesis. It may also play a role in controlling cellular adhesion. In breast carcinomas, PLK3 gene expression is significantly correlated with patient survival time.;

GenBank Accession Number : NM_004073;

Details

Origin ID

C51198;

UMLS CUI

C1704804;

OMIM relation
- Polo-like kinase 3 [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
gene_found_in_organism
- Human [NCIt concept]
gene_has_physical_location
- 1: 44935129-44940760 [NCIt concept]
gene_in_chromosomal_location
- 1p34.1 [NCIt concept]
gene_is_element_in_pathway
- Cell Cycle Progression Pathway [NCIt concept]
- PLK3 Signaling Pathway [NCIt concept]
- p53 Effector Pathway [NCIt concept]
gene_plays_role_in_process
- Cell Cycle Regulation Process [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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