" /> Caspase-3 - CISMeF





Preferred Label : Caspase-3;

NCIt synonyms : CPP32B; Caspase 3, Apoptosis-Related Cysteine Protease; Apopain; Yama; CPP-32; CASP-3; Cysteine Protease CPP32; CASP3; CPP32; SCA-1; Pro-Caspase 3; PARP Cleavage Protease; SREBP Cleavage Activity 1; EC 3.4.22.56; Protein Yama; Procaspase-3; Pro-Caspase-3; Procaspase 3;

NCIt definition : Caspase-3 (277 aa, 31 kDa) is encoded by the human CASP3 gene. This protein is involved in the mediation of proteolysis and the activation of apoptosis.;

NCIt note : Caspase-3 is a central player in mediating apoptosis and is the most widely studied caspase. This protein cleaves and activates caspases 6, 7 and 9, and itself can be processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.;

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28/04/2024


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