NCIt definition : Caspase-3 (277 aa, 31 kDa) is encoded by the human CASP3 gene. This protein is involved
in the mediation of proteolysis and the activation of apoptosis.;
NCIt note : Caspase-3 is a central player in mediating apoptosis and is the most widely studied
caspase. This protein cleaves and activates caspases 6, 7 and 9, and itself can be
processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage
of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's
disease.;