TSP-1 Induced Apoptosis Pathway

Preferred Label : TSP-1 Induced Apoptosis Pathway;

NCIt related terms : TSP-1 Induced Apoptosis in Microvascular Endothelial Cell;

Alternative definition : BIOCARTA: As tissues grow they require angiogenesis to occur if they are to be supplied with blood vessels and survive. Factors that inhibit angiogenesis might act as cancer therapeutics by blocking vessel formation in tumors and starving cancer cells. Thrombospondin-1 (TSP-1) is a protein that inhibits angiogenesis and slows tumor growth, apparently by inducing apoptosis of microvascular endothelial cells that line blood vessels. TSP-1 appears to produce this response by activating a signaling pathway that begins with its receptor, CD36, at the cell surface of the microvascular endothelial cell. The non-receptor tyrosine kinase fyn is activated by TSP-1 through CD36, activating the apoptosis inducing proteases such as caspase-3 and p38 protein kinases. p38 is a mitogen-activated kinase that also induces apoptosis in some conditions, perhaps through AP-1 activation and the activation of genes that lead to apoptosis. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_tsp1Pathway;

Details

Origin ID

C39260;

UMLS CUI

C1515180;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Caspase-3 [NCIt concept]
- Granzyme A [NCIt concept]
- Mitogen-Activated Protein Kinase 14 [NCIt concept]
- Platelet Glycoprotein 4 [NCIt concept]
- Proto-Oncogene c-Fos [NCIt concept]
- STE20-Like Serine/Threonine-Protein Kinase [NCIt concept]
- Thrombospondin-1 [NCIt concept]
- Transcription Factor AP-1 [NCIt concept]
- Tyrosine-Protein Kinase Fyn [NCIt concept]
pathway_has_gene_element
- CASP3 wt Allele [NCIt concept]
- CD36 wt Allele [NCIt concept]
- FOS wt Allele [NCIt concept]
- FYN wt Allele [NCIt concept]
- GZMA wt Allele [NCIt concept]
- JUN wt Allele [NCIt concept]
- MAPK14 wt Allele [NCIt concept]
- SLK wt Allele [NCIt concept]
- THBS1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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