Apoptotic DNA Fragmentation Pathway

Preferred Label : Apoptotic DNA Fragmentation Pathway;

NCIt related terms : Apoptotic DNA fragmentation and tissue homeostasis;

Alternative definition : BIOCARTA: Apoptotic cell death can be triggered by many different cellular stimuli, resulting in activation of apoptotic signaling pathways including caspases and mitochondria. A cellular response that is characteristic of apoptosis is fragmentation of the nuclear genome to create a nucleosomal ladder. This activity is conducted by multiple nucleases activated by apoptotic signaling pathways. One nuclease involved in apoptosis is DNA fragmentation factor (DFF), a caspase-activated DNAse (CAD). DFF/CAD is activated through cleavage of its associated inhibitor ICAD by caspases proteases during apoptosis. DFF/CAD interacts with chromatin components such as topo II and histone H1 to condense chromatin structure and perhaps recruit CAD to chromatin. Another apoptosis activated protease is endonuclease G, EndoG. EndoG is encoded in the nuclear genome but is localized to mitochondria in normal cells. EndoG may play a role in the replication of the mitochondrial genome, as well as in apoptosis. Apoptotic signaling causes the release of EndoG from mitochondria. Mitochondria are involved in apoptotic signaling in other ways as well, through the release of cytochrome c induced by Bid to activate the caspase protease cascade. These pathways are independent since the EndoG pathway still occurs in cells lacking DFF. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_DNAfragmentPathway;

Details

Origin ID

C39051;

UMLS CUI

C1516045;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- Caspase-3 [NCIt concept]
- Caspase-7 [NCIt concept]
- DNA Fragmentation Factor Subunit Beta [NCIt concept]
- DNA Topoisomerase 2-Alpha [NCIt concept]
- Granzyme B [NCIt concept]
- High Mobility Group Protein B1 [NCIt concept]
- High Mobility Group Protein B2 [NCIt concept]
pathway_has_gene_element
- CASP3 wt Allele [NCIt concept]
- CASP7 wt Allele [NCIt concept]
- DFFB wt Allele [NCIt concept]
- GZMB wt Allele [NCIt concept]
- HMGB1 wt Allele [NCIt concept]
- HMGB2 wt Allele [NCIt concept]
- TOP2A wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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