Preferred Label : High Mobility Group Protein B2;
NCIt synonyms : High-Mobility Group Box 2; HMGB2 Protein; High Mobility Group Box 2; HMG2; HMG 2; High Mobility Group Protein 2; HMG-2; HMGB2; Chromosomal Protein, Nonhistone, HMG2; High-Mobility Group (Nonhistone Chromosomal) Protein 2; Nonhistone Chromosomal Protein HMG2;
CISMeF acronym : HMGB2;
NCIt definition : High mobility group protein B2 (209 aa, 24 kDa) is encoded by the human HMGB2 gene.
This protein plays a role in DNA unwinding.;
NCIt note : HMGB2 contains two DNA-binding HMG-box domains (A and B) and a long acidic C-terminal
domain. It binds DNA without sequence specificity, but has a high affinity for bent
or distorted DNA, and bend linear DNA. The individual A and B boxes (which, although
broadly similar, show both structural and functional differences) exhibit many of
the structure-specific properties of the whole protein. The acidic tail modulates
the affinity of the tandem HMG boxes in HMG2 for a variety of DNA targets, including
four-way junctions, but not distorted DNA minicircles, to which the proteins bind
with very high affinity. HMGB2 appears to play important architectural roles in the
assembly of nucleoprotein complexes in a variety of biological processes, for example
V(D)J recombination, the initiation of transcription, and DNA repair. (Biochem Soc
Trans 2001; 29:395-401.);
Origin ID : C20330;
UMLS CUI : C5441587;
Currated CISMeF NLP mapping
- OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- gene_encodes_gene_product
- gene_product_has_biochemical_function
- gene_product_has_chemical_classification
- gene_product_has_organism_source
- gene_product_is_element_in_pathway
- gene_product_plays_role_in_biological_process
