V(D)J Recombination

Preferred Label : V(D)J Recombination;

NCIt synonyms : Immunoglobulin V(D)J Rearrangement; V(D)J Rearrangement; V-D-J Recombination;

NCIt definition : Any process of gene rearrangement in which the original variable and joining region coding segments of the immunoglobulin and T cell receptor genes are ligated to create a novel protein-coding capacity. This process may occur with inclusion of the diversity coding segment to create a V(D)J coding gene. V(D)J recombination is involved in generation of diversity for both antibody and T cell receptor responses.;

Details

Origin ID

C20971;

UMLS CUI

C1519877;

Currated CISMeF NLP mapping
- V(D)J recombination [MeSH Descriptor]
- V(D)J recombination [MeSH concept]
False automatic mappings
- V(D)J recombination [GO term]
Semantic type(s)
- Genetic Function [UMLS semantic type]
UMLS correspondences (same concept)
- V(D)J recombination [MeSH concept]
- V(D)J recombination [MeSH Descriptor]
- V(D)J recombination [GO term]
biological_process_has_initiator_process
- Cell Differentiation Process [NCIt concept]
biological_process_involves_gene_product
- DNA Ligase 4 [NCIt concept]
- DNA Repair Protein XRCC4 [NCIt concept]
- DNA-Dependent Protein Kinase Catalytic Subunit [NCIt concept]
- High Mobility Group Protein B1 [NCIt concept]
- High Mobility Group Protein B2 [NCIt concept]
- Histone H2AX [NCIt concept]
- Interleukin-7 [NCIt concept]
- Interleukin-7 Receptor Subunit Alpha [NCIt concept]
- Ku Protein [NCIt concept]
- Nibrin [NCIt concept]
- Nonhomologous End-Joining Factor 1 [NCIt concept]
- Protein Artemis [NCIt concept]
- V(D)J Recombination-Activating Protein 1 [NCIt concept]
- V(D)J Recombination-Activating Protein 2 [NCIt concept]
- X-Ray Repair Cross-Complementing Protein 5 [NCIt concept]
- X-Ray Repair Cross-Complementing Protein 6 [NCIt concept]
biological_process_is_part_of_process
- Immune Response Process [NCIt concept]
- Immune System Process [NCIt concept]
process_involves_gene
- DCLRE1C Gene [NCIt concept]
- DCLRE1C wt Allele [NCIt concept]
- H2AX Gene [NCIt concept]
- H2AX wt Allele [NCIt concept]
- HMGB1 Gene [NCIt concept]
- HMGB1 wt Allele [NCIt concept]
- HMGB2 Gene [NCIt concept]
- HMGB2 wt Allele [NCIt concept]
- IL7 Gene [NCIt concept]
- IL7 wt Allele [NCIt concept]
- IL7R Gene [NCIt concept]
- IL7R wt Allele [NCIt concept]
- Ku Subunit Gene [NCIt concept]
- LIG4 Gene [NCIt concept]
- LIG4 wt Allele [NCIt concept]
- NBN Gene [NCIt concept]
- NBN wt Allele [NCIt concept]
- NHEJ1 Gene [NCIt concept]
- NHEJ1 wt Allele [NCIt concept]
- PRKDC Gene [NCIt concept]
- PRKDC wt Allele [NCIt concept]
- RAG1 Gene [NCIt concept]
- RAG1 wt Allele [NCIt concept]
- RAG2 Gene [NCIt concept]
- RAG2 wt Allele [NCIt concept]
- XRCC4 Gene [NCIt concept]
- XRCC4 wt Allele [NCIt concept]
- XRCC5 Gene [NCIt concept]
- XRCC5 wt Allele [NCIt concept]
- XRCC6 Gene [NCIt concept]
- XRCC6 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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