DNA Ligase 4 - CISMeF

Preferred Label : DNA Ligase 4;

NCIt synonyms : EC 6.5.1.1; Ligase IV, DNA, ATP-Dependent; LIG4; Polydeoxyribonucleotide Synthase; DNA Repair Enzyme; Sealase; DNA Joinase; Polynucleotide Ligase; DNA Ligase IV; Polydeoxyribonucleotide Synthase [ATP] 4; DNA Ligase-IV;

NCIt definition : DNA ligase 4 (911 aa, 104 kDa) is encoded by the human LIG4 gene. This protein plays a role in non-homologous end joining during both DNA repair and V(D)J recombination.;

Details

Origin ID

C21463;

UMLS CUI

C1442799;

Automatic exact mappings (from CISMeF team)
- Cdc17 protein, S pombe [MeSH Supplementary Concept]
- DNA Ligase ATP [MeSH Descriptor]
- DNA ligase (ATP) activity [GO term]
- DNA ligase (NAD+) activity [GO term]
- DNA ligase 4 [HGNC gene]
- DNA ligase 4 [ORDO Gene]
- DNA ligases [MeSH Descriptor]
- DNA ligases [MeSH concept]
- Isoleucine-tRNA ligase [MeSH Descriptor]
- Ligase iv, dna, atp-dependent [OMIM gene]
- damaged DNA binding [GO term]
- formyltetrahydrofolate dehydrogenase [MeSH Supplementary Concept]
- tilS protein, E coli [MeSH Supplementary Concept]
OMIM relation
- Ligase iv, dna, atp-dependent [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- LIG4 protein, human [MeSH Supplementary Concept]
- LIG4 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- LIG4 Gene [NCIt concept]
- Ligase Gene [NCIt concept]
gene_product_expressed_in_tissue
- Heart [NCIt concept]
- Prostate Gland [NCIt concept]
- Testis [NCIt concept]
- Thymus Gland [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- DNA Repair Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- BRCT Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Non-Homologous End-Joining Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Nonhomologous DNA End Joining [NCIt concept]
- V(D)J Recombination [NCIt concept]

Keyword's position in hierarchy(ies) :

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