Non-Homologous End-Joining Pathway

Preferred Label : Non-Homologous End-Joining Pathway;

NCIt synonyms : NHEJ Pathway;

NCIt related terms : Non-homologous end-joining;

Alternative definition : KEGG: Nonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX complex in yeast), processing of ends, and recruitment of the DNA ligase IV (LIG4)-XRCC4 complex, which brings about ligation. A recent study shows that bacteria accomplish NHEJ using just two proteins (Ku and DNA ligase), whereas eukaryotes require many factors. NHEJ repairs DSBs at all stages of the cell cycle, bringing about the ligation of two DNA DSBs without the need for sequence homology, and so is error-prone.;

KEGG ID : hsa03450;

Details

Origin ID

C91444;

UMLS CUI

C2984257;

Semantic type(s)
- Functional Concept [UMLS semantic type]
has_gene_product_element
- DNA Ligase 4 [NCIt concept]
- DNA Repair Protein RAD50 [NCIt concept]
- DNA Repair Protein XRCC4 [NCIt concept]
- DNA-Dependent Protein Kinase Catalytic Subunit [NCIt concept]
- Double-Strand Break Repair Protein MRE11 [NCIt concept]
- Flap Endonuclease 1 [NCIt concept]
- Nonhomologous End-Joining Factor 1 [NCIt concept]
- TP53-Binding Protein 1 [NCIt concept]
- X-Ray Repair Cross-Complementing Protein 5 [NCIt concept]
- X-Ray Repair Cross-Complementing Protein 6 [NCIt concept]
pathway_has_gene_element
- FEN1 wt Allele [NCIt concept]
- LIG4 wt Allele [NCIt concept]
- MRE11 wt Allele [NCIt concept]
- NHEJ1 wt Allele [NCIt concept]
- PRKDC wt Allele [NCIt concept]
- RAD50 wt Allele [NCIt concept]
- TP53BP1 wt Allele [NCIt concept]
- XRCC4 wt Allele [NCIt concept]
- XRCC5 wt Allele [NCIt concept]
- XRCC6 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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