X-Ray Repair Cross-Complementing Protein 6

Preferred Label : X-Ray Repair Cross-Complementing Protein 6;

NCIt synonyms : G22P1; Lupus Ku Autoantigen Protein p70; Thyroid-Lupus Autoantigen p70; Lupus Autoantigen p70; Thyroid-Lupus Autoantigen; Thyroid Autoantigen 70kD; CTC Box-Binding Factor 75 kDa Subunit; 70 kDa Subunit of Ku Antigen; DNA Repair Protein XRCC6; CTC75; ATP-Dependent DNA Helicase 2 Subunit 1; 5'-dRP Lyase Ku70; Ku Autoantigen p70 Subunit; 5'-Deoxyribose-5-Phosphate Lyase Ku70; X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 6; Ku70; EC 3.6.4.-; EC 4.2.99.-; Ku70 Protein; CTC Box Binding Factor 75 kDa Subunit; ATP-Dependent DNA Helicase II 70 kDa Subunit; TLAA;

NCIt definition : X-ray repair cross-complementing protein 6 (609 aa, 70 kDa) is encoded by the human XRCC6 gene. This protein plays a role in DNA non-homologous end joining, which is required for both double-strand break repair and V(D)J recombination.;

NCIt note : X-ray repair cross-complementing protein 6 is found in a heterodimeric complex with X-ray repair cross-complementing protein 5 to form the DNA helicase II complex (Ku).;

NCI Metathesaurus CUI : CL599582;

Details

Origin ID

C20023;

UMLS CUI

C4308049;

OMIM relation
- X-ray repair cross complementing 6 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- Ku70 antigen [MeSH concept]
- Xrcc6 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- DNA Repair Gene [NCIt concept]
- XRCC6 Gene [NCIt concept]
gene_product_has_biochemical_function
- Helicase [NCIt concept]
gene_product_is_element_in_pathway
- BARD1 Signaling Pathway [NCIt concept]
- Coregulation Pathway for Androgen Receptor Activity [NCIt concept]
- HDAC Class III Signaling Pathway [NCIt concept]
- Non-Homologous End-Joining Pathway [NCIt concept]
- Telomerase Regulation Pathway [NCIt concept]
- Telomere Pathway [NCIt concept]
gene_product_is_physical_part_of
- Ku Protein [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Repair [NCIt concept]
- Nonhomologous DNA End Joining [NCIt concept]
- Telomere Maintenance [NCIt concept]
- V(D)J Recombination [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients