Nonhomologous DNA End Joining

Preferred Label : Nonhomologous DNA End Joining;

NCIt synonyms : Non-Homologous End Joining; NHEJ;

NCIt definition : Non-homologous DNA end joining (NHEJ) can only repair double-strand breaks in which two DNA ends are rejoined by DNA ligase at regions of little or no homology to avoid degradation by DNA nucleases or noncomplementary overhanging ends. However, the disadvantage is that it can lead to loss of information from the DNA because of resection of the broken ends. NHEJ is operational throughout the cell cycle but may be more important during G1, prior to DNA replication, or in cells that are no longer cycling.;

Details

Origin ID

C20207;

UMLS CUI

C1518406;

Automatic exact mappings (from CISMeF team)
- DNA End-Joining repair [MeSH Descriptor]
- Non-Homologous DNA End-Joining [MeSH concept]
- double-strand break repair via nonhomologous end joining [GO term]
Semantic type(s)
- Genetic Function [UMLS semantic type]
UMLS correspondences (same concept)
- Non-Homologous DNA End-Joining [MeSH concept]
- double-strand break repair via nonhomologous end joining [GO term]
biological_process_involves_gene_product
- DNA Ligase 4 [NCIt concept]
- DNA Repair Protein XRCC4 [NCIt concept]
- DNA-Dependent Protein Kinase Catalytic Subunit [NCIt concept]
- Double-Strand Break Repair Protein MRE11 [NCIt concept]
- Ku Protein [NCIt concept]
- Nonhomologous End-Joining Factor 1 [NCIt concept]
- Protein Artemis [NCIt concept]
- TP53-Binding Protein 1 [NCIt concept]
- X-Ray Repair Cross-Complementing Protein 5 [NCIt concept]
- X-Ray Repair Cross-Complementing Protein 6 [NCIt concept]
biological_process_is_part_of_process
- Cell Survival [NCIt concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
process_involves_gene
- DCLRE1C Gene [NCIt concept]
- DCLRE1C wt Allele [NCIt concept]
- Ku Subunit Gene [NCIt concept]
- LIG4 Gene [NCIt concept]
- LIG4 wt Allele [NCIt concept]
- MRE11 Gene [NCIt concept]
- MRE11 wt Allele [NCIt concept]
- NHEJ1 Gene [NCIt concept]
- NHEJ1 wt Allele [NCIt concept]
- PRKDC Gene [NCIt concept]
- PRKDC wt Allele [NCIt concept]
- TP53BP1 Gene [NCIt concept]
- TP53BP1 wt Allele [NCIt concept]
- XRCC4 Gene [NCIt concept]
- XRCC4 wt Allele [NCIt concept]
- XRCC5 Gene [NCIt concept]
- XRCC5 wt Allele [NCIt concept]
- XRCC6 Gene [NCIt concept]
- XRCC6 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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