DNA-Dependent Protein Kinase Complex

Preferred Label : DNA-Dependent Protein Kinase Complex;

NCIt synonyms : DNA-PK; DNA-Dependent Protein Kinase; DNA-PK Complex;

NCIt definition : A heterotrimeric complex of the DNA-dependent protein kinase catalytic subunit protein (PRKDC or DNA-PKcs) and the Ku protein, which is a heterodimer composed of X-ray repair cross-complementing proteins 5 and 6, XRCC5/Ku86 and XRCC6/Ku70, respectively. This complex is involved in ribosome assembly, DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination, and serine/threonine phosphorylation of proteins involved in DNA damage response/repair.;

Détails

Origin ID

C212140;

concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Pediatric Oncology Biomarkers/Targets Associated with Other Relevant Evidence [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Serine/Threonine Protein Kinase [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Repair [NCIt concept]
- Nonhomologous DNA End Joining [NCIt concept]
- Ribosomal Interaction [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- V(D)J Recombination [NCIt concept]
has_gene_product_element
- DNA-Dependent Protein Kinase Catalytic Subunit [NCIt concept]
- Ku Protein [NCIt concept]

Position du mot-clé dans l'(les) arborescence(s) :

Vous pouvez consulter :

recommendations
documents concerning education
documents for patients