DNA-Dependent Protein Kinase Catalytic Subunit

Preferred Label : DNA-Dependent Protein Kinase Catalytic Subunit;

NCIt synonyms : Hyper-Radiosensitivity Of Murine SCID Mutation, Complementing 1; p350; PRKDC; DNA-Dependent Protein Kinase; DNPK1; XRCC7; DNAPK; HYRC1; p460; DNA-PKcs; DNA-PK Catalytic Subunit; DNA-Activated Protein Kinase Catalytic Subunit; EC 2.7.11.1; Protein Kinase DNA-Activated Catalytic Subunit; DNA-Dependent Protein Kinase, Catalytic Subunit;

NCIt definition : DNA-dependent protein kinase catalytic subunit (4128 aa, 469 kDa) is encoded by the human PRKDC gene. This protein is involved in both DNA damage response and protein phosphorylation.;

Details

Origin ID

C21483;

UMLS CUI

C1528018;

OMIM relation
- Protein kinase, dna-activated, catalytic subunit [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- PRKDC protein, human [MeSH concept]
- PRKDC protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- DNA Repair Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- PRKDC Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
- Tetratricopeptide Repeat [NCIt concept]
gene_product_is_element_in_pathway
- BARD1 Signaling Pathway [NCIt concept]
- Cell Cycle Pathway [NCIt concept]
- Coregulation Pathway for Androgen Receptor Activity [NCIt concept]
- Fas Signaling Pathway BioCarta [NCIt concept]
- G2/M Checkpoint Pathway [NCIt concept]
- HIV-I Nef in Apoptosis Pathway [NCIt concept]
- Non-Homologous End-Joining Pathway [NCIt concept]
- PI3K/AKT1 Signaling Pathway [NCIt concept]
- TNFR1 Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Recombination Process [NCIt concept]
- DNA Repair [NCIt concept]
- Nonhomologous DNA End Joining [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Telomere Capping [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- V(D)J Recombination [NCIt concept]
is_target
- ATM Kinase/DNA-PK Inhibitor XRD-0394 [NCIt concept]
- DNA-PK inhibitor AZD7648 [NCIt concept]
- DNA-PK/TOR Kinase Inhibitor CC-115 [NCIt concept]
- DNA-dependent Protein Kinase Inhibitor VX-984 [NCIt concept]
- Panulisib [NCIt concept]
- Peposertib [NCIt concept]

Keyword's position in hierarchy(ies) :

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