Preferred Label : DNA-dependent Protein Kinase Inhibitor VX-984;
NCIt synonyms : DNA-PK Inhibitor VX-984;
NCIt related terms : VX-984;
NCIt definition : An ATP-competitive inhibitor of the catalytic subunit of DNA-dependent protein kinase
(DNA-PK), with potential sensitizing and enhancing activities for both chemo- and
radiotherapies. Upon administration, DNA-PK inhibitor VX-984 binds to and inhibits
the catalytic subunit of DNA-PK, thereby interfering with the non-homologous end joining
(NHEJ) process and preventing repair of DNA double strand breaks (DSBs) caused by
ionizing radiation or chemotherapeutic treatment. This increases chemo- and radiotherapy
cytotoxicity and leads to enhanced tumor cell death. The enhanced ability of tumor
cells to repair DSBs plays a major role in the resistance of tumor cells to chemo-
and radiotherapy; DNA-PK plays a key role in the NHEJ pathway and DSB repair.;
UNII : 0C33IBK195;
CAS number : 1476074-39-1;
Molecule name : VX-984;
NCI Metathesaurus CUI : CL512131;
Origin ID : C129061;
UMLS CUI : C4287694;
Semantic type(s)
concept_is_in_subset
has_target