Preferred Label : DNA-PK/TOR Kinase Inhibitor CC-115;
NCIt related terms : CC-115;
NCIt definition : A dual inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of
rapamycin (mTOR), with potential antineoplastic activity. CC-115 binds to and inhibits
the activity of DNA-PK and both raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR
(TOR complex 2 or TORC2), which may lead to a reduction in cellular proliferation
of cancer cells expressing DNA-PK and TOR. DNA-PK, a serine/threonine kinase and a
member of the PI3K-related kinase subfamily of protein kinases, is activated upon
DNA damage and plays a key role in repairing double-stranded DNA breaks via the DNA
nonhomologous end joining (NHEJ) pathway; mTOR, a serine/threonine kinase that is
upregulated in a variety of tumors, plays an important role downstream in the PI3K/Akt/mTOR
signaling pathway.;
UNII : FII75TFH5L;
CAS number : 1228013-15-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1228013-15-7
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : CC-115;
Origin ID : C97040;
UMLS CUI : C3273208;
Semantic type(s)
- concept_is_in_subset
- has_target
