mTORC1 - CISMeF

Preferred Label : mTORC1;

NCIt synonyms : mTOR Complex 1; Raptor-mTOR; Target of Rapamycin Complex 1; TOR Complex 1; Raptor/TORC1; TORC1; Mammalian Target of Rapamycin Complex 1;

NCIt definition : A protein complex that is involved in the both serine/threonine phosphorylation and the regulation of protein synthesis in response to cellular stress.;

NCIt note : The activity of this complex is inhibited by rapamycin.; mTORC1 is comprised of serine/threonine-protein kinase mTOR, regulatory-associated protein of mTOR, proline-rich AKT1 substrate 1 and target of rapamycin complex subunit LST8. (UniProt);

Details

Origin ID

C96314;

UMLS CUI

C3888046;

Automatic exact mappings (from CISMeF team)
- Creb-regulated transcription coactivator 1 [OMIM gene]
- Mechanistic Target of Rapamycin Complex 1 [MeSH Descriptor]
- Mechanistic target of rapamycin [OMIM gene]
- TORC1 complex [GO term]
- mechanistic target of rapamycin complex 1 [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Mechanistic Target of Rapamycin Complex 1 [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_product_is_element_in_pathway
- Hepatocyte Growth Factor Receptor Signaling Pathway PID [NCIt concept]
- mTOR Signaling Pathway PID [NCIt concept]
gene_product_plays_role_in_biological_process
- Serine/Threonine Phosphorylation [NCIt concept]
- Translational Activation [NCIt concept]
has_gene_product_element
- DEP Domain-Containing mTOR-Interacting Protein [NCIt concept]
- Proline-Rich AKT1 Substrate 1 [NCIt concept]
- Serine/Threonine-Protein Kinase mTOR [NCIt concept]
- Target of Rapamycin Complex Subunit LST8 [NCIt concept]
is_target
- DNA-PK/TOR Kinase Inhibitor CC-115 [NCIt concept]
- Encapsulated Rapamycin [NCIt concept]
- Sapanisertib [NCIt concept]
- mTOR Kinase Inhibitor AZD8055 [NCIt concept]
- mTOR Kinase Inhibitor CERC-006 [NCIt concept]
- mTORC1 Kinase Inhibitor RMC-5552 [NCIt concept]
- mTORC1/mTORC2 Inhibitor Palomid 529 [NCIt concept]
- mTORC1/mTORC2 Inhibitor XL388 [NCIt concept]

Keyword's position in hierarchy(ies) :

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