mTOR Signaling Pathway PID

Preferred Label : mTOR Signaling Pathway PID;

NCIt related terms : mTOR signaling pathway;

NCIt definition : A complex set of signal transduction pathways described by the NCI Pathway Interaction Database (PID), where each pathway is dependent on the activity of serine/threonine-protein kinase mTOR. This kinase is part of 2 structurally and functionally distinct signaling complexes, mTOR complex 1 and 2 (mTORC1 and mTORC2, respectively), which together regulate the expression of genes that respond to cellular exposure to hormones, growth factors, nutrients and stress signals.;

Details

Origin ID

C91634;

UMLS CUI

C2984436;

Semantic type(s)
- Molecular Function [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
has_gene_product_element
- 14-3-3 Protein Sigma [NCIt concept]
- 14-3-3 Protein Theta [NCIt concept]
- 3-Phosphoinositide-Dependent Protein Kinase 1 [NCIt concept]
- BCL2/Adenovirus E1B 19 kDa Protein-Interacting Protein 3 [NCIt concept]
- DEP Domain-Containing mTOR-Interacting Protein [NCIt concept]
- Eukaryotic Elongation Factor 2 Kinase [NCIt concept]
- Eukaryotic Translation Initiation Factor 4B [NCIt concept]
- Eukaryotic Translation Initiation Factor 4E [NCIt concept]
- Eukaryotic Translation Initiation Factor 4E-Binding Protein 1 [NCIt concept]
- GTP-Binding Protein Rheb [NCIt concept]
- GTPase KRas [NCIt concept]
- Hamartin [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta [NCIt concept]
- Paxillin [NCIt concept]
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha [NCIt concept]
- Programmed Cell Death Protein 4 [NCIt concept]
- Proline-Rich AKT1 Substrate 1 [NCIt concept]
- Protein Kinase C Alpha Type [NCIt concept]
- Protein PML [NCIt concept]
- RAC-Alpha Serine/Threonine Kinase [NCIt concept]
- RAS-Related GTP-Binding Protein A [NCIt concept]
- Ras-Related C3 Botulinum Toxin Substrate 1 [NCIt concept]
- Ras-Related GTP-Binding Protein C [NCIt concept]
- Ras-Related GTP-Binding Protein D [NCIt concept]
- Ribosomal Protein S6 Kinase Alpha-1 [NCIt concept]
- Serine/Threonine-Protein Kinase Sgk1 [NCIt concept]
- Serine/Threonine-Protein Kinase ULK2 [NCIt concept]
- Serine/Threonine-Protein Kinase mTOR [NCIt concept]
- Sterol Regulatory Element-Binding Protein 1 [NCIt concept]
- Target of Rapamycin Complex 2 Subunit MAPKAP1 [NCIt concept]
- Target of Rapamycin Complex Subunit LST8 [NCIt concept]
- Transcriptional Repressor Protein YY1 [NCIt concept]
- Tuberin [NCIt concept]
- [Pyruvate Dehydrogenase [Lipoamide]] Kinase Isozyme 1, Mitochondrial [NCIt concept]
- mTORC1 [NCIt concept]
- mTORC2 [NCIt concept]
pathway_has_gene_element
- AKT1 wt Allele [NCIt concept]
- AKT1S1 wt Allele [NCIt concept]
- BNIP3 wt Allele [NCIt concept]
- DEPTOR wt Allele [NCIt concept]
- EEF2K wt Allele [NCIt concept]
- EIF4B wt Allele [NCIt concept]
- EIF4E wt Allele [NCIt concept]
- EIF4EBP1 wt Allele [NCIt concept]
- IKBKB wt Allele [NCIt concept]
- KRAS wt Allele [NCIt concept]
- MAPKAP1 wt Allele [NCIt concept]
- MLST8 wt Allele [NCIt concept]
- MTOR wt Allele [NCIt concept]
- PDCD4 wt Allele [NCIt concept]
- PDK1 wt Allele [NCIt concept]
- PDPK1 wt Allele [NCIt concept]
- PML wt Allele [NCIt concept]
- PPARGC1A wt Allele [NCIt concept]
- PRKCA wt Allele [NCIt concept]
- PXN wt Allele [NCIt concept]
- RAC1 wt Allele [NCIt concept]
- RHEB wt Allele [NCIt concept]
- RPS6KA1 wt Allele [NCIt concept]
- RRAGA wt Allele [NCIt concept]
- RRAGC wt Allele [NCIt concept]
- RRAGD wt Allele [NCIt concept]
- SFN wt Allele [NCIt concept]
- SGK1 wt Allele [NCIt concept]
- SREBF1 wt Allele [NCIt concept]
- TSC1 wt Allele [NCIt concept]
- TSC2 wt Allele [NCIt concept]
- ULK2 wt Allele [NCIt concept]
- YWHAQ wt Allele [NCIt concept]
- YY1 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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