mTOR Kinase Inhibitor CERC-006

Preferred Label : mTOR Kinase Inhibitor CERC-006;

NCIt synonyms : Mammalian Target of Rapamycin Kinase Inhibitor OSI-027; mTOR Kinase Inhibitor OSI-027;

NCIt related terms : OSI-027;

NCIt definition : An orally bioavailable mammalian target of rapamycin (mTOR) kinase inhibitor, with potential antineoplastic activity. Upon oral administration, mTOR kinase inhibitor CERC-006 binds to and inhibits both the raptor-mTOR (TOR complex 1 or TORC1) and the rictor-mTOR (TOR complex 2 or TORC2) complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation. mTOR is a serine/threonine kinase that is upregulated in some tumors and plays an important role downstream in the PI3K/Akt/mTOR signaling pathway.;

UNII : 25MKH1SZ0M;

InChIKey : JROFGZPOBKIAEW-HAQNSBGRSA-N;

CAS number : 936890-98-1;

Molecule name : OSI-027; CERC-006; ASP 7486; AEVI-006; AEVI 006; ASP-7486; CERC 006;

Details

Origin ID

C78476;

UMLS CUI

C2703121;

Currated CISMeF NLP mapping
- OSI 027 [MeSH concept]
- OSI 027 [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- OSI 027 [MeSH concept]
- OSI 027 [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- mTORC1 [NCIt concept]
- mTORC2 [NCIt concept]

Keyword's position in hierarchy(ies) :

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