mTORC2 - CISMeF

Preferred Label : mTORC2;

NCIt synonyms : mTOR Complex 2; Target of Rapamycin Complex 2; Rictor-mTOR; Rictor/TORC2; TORC2; TOR Complex 2; Mammalian Target of Rapamycin Complex 2;

NCIt definition : A protein complex that is involved in both serine/threonine phosphorylation and cytoskeleton remodeling in response to cellular stress.;

NCIt note : mTORC2 is comprised of serine/threonine-protein kinase mTOR, rapamycin-insensitive companion of mTOR, proline-rich protein 5, target of rapamycin complex 2 subunit MAPKAP1 and target of rapamycin complex subunit LST8. (UniProt);

Details

Origin ID

C96315;

UMLS CUI

C3152112;

Automatic exact mappings (from CISMeF team)
- Creb-regulated transcription coactivator 2 [OMIM gene]
- Mechanistic target of rapamycin [OMIM gene]
Currated CISMeF NLP mapping
- Mechanistic Target of Rapamycin Complex 2 [MeSH concept]
- Mechanistic Target of Rapamycin Complex 2 [MeSH Descriptor]
- TORC2 complex [GO term]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Mechanistic Target of Rapamycin Complex 2 [MeSH concept]
- Mechanistic Target of Rapamycin Complex 2 [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_product_is_element_in_pathway
- CXCR3-Mediated Signaling Pathway [NCIt concept]
- CXCR4-Mediated Signaling Pathway [NCIt concept]
- Epidermal Growth Factor Receptor Downstream Signaling Pathway [NCIt concept]
- PI3K/AKT1 Signaling Pathway [NCIt concept]
- mTOR Signaling Pathway PID [NCIt concept]
gene_product_plays_role_in_biological_process
- Serine/Threonine Phosphorylation [NCIt concept]
has_gene_product_element
- DEP Domain-Containing mTOR-Interacting Protein [NCIt concept]
- Serine/Threonine-Protein Kinase mTOR [NCIt concept]
- Target of Rapamycin Complex 2 Subunit MAPKAP1 [NCIt concept]
- Target of Rapamycin Complex Subunit LST8 [NCIt concept]
is_target
- DNA-PK/TOR Kinase Inhibitor CC-115 [NCIt concept]
- Encapsulated Rapamycin [NCIt concept]
- Sapanisertib [NCIt concept]
- mTOR Kinase Inhibitor AZD8055 [NCIt concept]
- mTOR Kinase Inhibitor CERC-006 [NCIt concept]
- mTORC1/mTORC2 Inhibitor Palomid 529 [NCIt concept]
- mTORC1/mTORC2 Inhibitor XL388 [NCIt concept]

Keyword's position in hierarchy(ies) :

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