Mechanistic Target of Rapamycin Complex 2 - CISMeF
Mechanistic Target of Rapamycin Complex 2MeSH Descriptor
Preferred Label : Mechanistic Target of Rapamycin Complex 2;
MeSH definition : A multiprotein complex consisting of MTOR KINASE; MLST8 PROTEIN; rapamycin-insensitive
companion of mTOR protein (RICTOR PROTEIN); and PRR5 (proline-rich protein 5). Like
MTORC1, it also regulates cell growth and proliferation in response to growth factors
but may not be as sensitive to nutrient availability and is insensitive to SIROLIMUS.
In contrast to MTORC1, it can regulate the ACTIN CYTOSKELETON through RHO GTPASES
to promote the formation of STRESS FIBERS. The mTORC2 complex also plays a critical
role in AKT1 PROTEIN KINASE phosphorylation and activation.;
MeSH synonym : TORC2; MTORC-2; mTORC2; TOR Complex 2; Complex 2, TOR; Target of Rapamycin Complex 2;
A multiprotein complex consisting of MTOR KINASE; MLST8 PROTEIN; rapamycin-insensitive
companion of mTOR protein (RICTOR PROTEIN); and PRR5 (proline-rich protein 5). Like
MTORC1, it also regulates cell growth and proliferation in response to growth factors
but may not be as sensitive to nutrient availability and is insensitive to SIROLIMUS.
In contrast to MTORC1, it can regulate the ACTIN CYTOSKELETON through RHO GTPASES
to promote the formation of STRESS FIBERS. The mTORC2 complex also plays a critical
role in AKT1 PROTEIN KINASE phosphorylation and activation.