Preferred Label : mTORC1/mTORC2 Inhibitor Palomid 529;
NCIt synonyms : TORC1/TORC2 Inhibitor Palomid 529; mTOR Inhibitor XL388;
NCIt related terms : PALOMID 529;
NCIt definition : An orally bioavailable inhibitor of raptor-mammalian target of rapamycin (mTOR) complex
1 (mTOR complex 1; mTORC1; TOR complex 1; TORC1) and rictor-mTOR (mTOR complex 2;
mTORC2; TOR complex 2; TORC2), with potential antineoplastic activity. Upon oral administration,
mTORC1/mTORC2 inhibitor palomid 529 targets, selectively binds to and inhibits both
mTORC1 and mTORC2, which may result in apoptosis and a decrease in proliferation in
mTORC1/2-expressing tumor cells. mTOR is a serine/threonine kinase that is upregulated
in some tumors; it plays an important role in the PI3K/Akt/mTOR signaling pathway
which is often deregulated in cancer cells.;
UNII : XV9409EWG4;
CAS number : 914913-88-5;
Molecule name : SG 00529; Palomid-529; P 529; Palomid 529; P-529; RES-529; Palmoid 529; RES 529; SG-00529;
NCI Metathesaurus CUI : CL1927581;
Origin ID : C205376;
concept_is_in_subset
- has_target
