Preferred Label : mTORC1/mTORC2 Inhibitor XL388;
NCIt synonyms : mTOR Inhibitor XL388; TORC1/TORC2 Inhibitor XL388;
NCIt related terms : XL-388;
NCIt definition : An orally bioavailable, ATP-competitive inhibitor of raptor-mammalian target of rapamycin
(mTOR) complex 1 (mTOR complex 1; mTORC1; TOR complex 1; TORC1) and rictor-mTOR (mTOR
complex 2; mTORC2; TOR complex 2; TORC2), with potential antineoplastic activity.
Upon oral administration, mTORC1/mTORC2 inhibitor XL388 targets, selectively binds
to and inhibits both mTORC1 and mTORC2, which may result in apoptosis and a decrease
in proliferation in mTORC1/2-expressing tumor cells. mTOR is a serine/threonine kinase
that is upregulated in some tumors; it plays an important role in the PI3K/Akt/mTOR
signaling pathway which is often deregulated in cancer cells.;
UNII : B7I5G3Z7XR;
CAS number : 251156-08-7;
Molecule name : XL 388; XL-388;
NCI Metathesaurus CUI : CL1927578;
Origin ID : C205375;
concept_is_in_subset
- has_target
