NCIt definition : An orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR
(TOR complex 2 or TORC2) with potential antineoplastic activity. Sapanisertib binds
to and inhibits both TORC1 and TORC2 complexes of mTOR, which may result in tumor
cell apoptosis and a decrease in tumor cell proliferation. TORC1 and 2 are upregulated
in some tumors and play an important role in the PI3K/Akt/mTOR signaling pathway,
which is frequently dysregulated in human cancers.;