" /> Sapanisertib - CISMeF





Preferred Label : Sapanisertib;

NCIt definition : An orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity. Sapanisertib binds to and inhibits both TORC1 and TORC2 complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation. TORC1 and 2 are upregulated in some tumors and play an important role in the PI3K/Akt/mTOR signaling pathway, which is frequently dysregulated in human cancers.;

UNII : JGH0DF1U03;

InChIKey : GYLDXIAOMVERTK-UHFFFAOYSA-N;

CAS number : 1224844-38-5;

Molecule name : INK-128; TAK-228; MLN-0128;

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09/05/2025


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