Sapanisertib - CISMeF

Preferred Label : Sapanisertib;

NCIt definition : An orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity. Sapanisertib binds to and inhibits both TORC1 and TORC2 complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation. TORC1 and 2 are upregulated in some tumors and play an important role in the PI3K/Akt/mTOR signaling pathway, which is frequently dysregulated in human cancers.;

UNII : JGH0DF1U03;

InChIKey : GYLDXIAOMVERTK-UHFFFAOYSA-N;

CAS number : 1224844-38-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1224844-38-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : INK-128; TAK-228; MLN-0128;

Details

Origin ID

C90548;

UMLS CUI

C4087082;

Currated CISMeF NLP mapping
- sapanisertib [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- sapanisertib [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- mTORC1 [NCIt concept]
- mTORC2 [NCIt concept]

Keyword's position in hierarchy(ies) :

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