" /> Serine/Threonine-Protein Kinase mTOR - CISMeF





Preferred Label : Serine/Threonine-Protein Kinase mTOR;

NCIt synonyms : Rapamycin Target Protein; mTOR; FK506 Binding Protein 12-Rapamycin Associated Protein 2; FRAP1; FK506 Binding Protein 12-Rapamycin Associated Protein 1; FKBP-Rapamycin Associated Protein; FRAP; RAPT1; FRAP2; RAFT1; FK506-Binding Protein 12-Rapamycin Complex-Associated Protein 1; Rapamycin Target Protein 1; FKBP12 Rapamycin Complex Associated Protein 1; FKBP12-Rapamycin Complex-Associated Protein; Mechanistic Target of Rapamycin; EC 2.7.11.1; FKBP12-Rapamycin Complex Associated Protein-1;

NCIt related terms : mammalian target of rapamycin;

NCIt definition : Serine/threonine-protein kinase mTOR (2549 aa, 289 kDa) is encoded by the human MTOR gene. This protein is involved in protein phosphorylation, signaling and cell growth.;

Alternative definition : NCI-GLOSS: A protein that helps control several cell functions, including cell division and survival, and binds to rapamycin and other drugs. Mammalian target of rapamycin may be more active in some types of cancer cells than it is in normal cells. Blocking mammalian target of rapamycin may cause the cancer cells to die. It is a type of serine/threonine protein kinase.;

NCIt note : FKBP12-Rapamycin Complex Associated Protein 1 contains 8 HEAT repeats and is a target for the G1 cell-cycle arrest and immunosuppressive effects of FKBP12-rapamycin complex. mTOR regulates ribosome biogenesis and cell growth in response to ATP or nutrient concentrations. FRAP phosphorylation of p53 (inhibited by rapamycin) downregulates PP2A, activates BAX, and induces mitochondrial membrane permeability and caspase activation. Mitogen-induced phospholipase D-dependent phosphatidic acid interacts with the mTOR rapamycin target domain. Cellular stress inhibits MTOR activity by stabilizing MTOR-RAPTOR binding, which also promotes MTOR phosphorylation of 4EBP1 and enhances MTOR activity toward S6K1. MTOR binds UBQLN1.;

Codes from synonyms : CDR0000653127;

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25/04/2024


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