NCIt definition : An orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with
potential antineoplastic activity. Vistusertib inhibits the activity of mTOR, which
may result in the induction of tumor cell apoptosis and a decrease in tumor cell proliferation.
mTOR, a serine/threonine kinase that is upregulated in a variety of tumors, plays
an important role downstream in the PI3K/Akt/mTOR signaling pathway.;