NCIt related terms : Sirolimus protein-bound particles;
NCIt definition : The macrolide antibiotic rapamycin bound to nanoparticle albumin with immunosuppressant
(see sirolimus) and potential antiangiogenic and antineoplastic activities. Rapamycin
binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate a complex that
binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR),
a key regulatory kinase. In turn, inhibition of mTOR may result in the inhibition
of the phosphatidylinositol 3 (PI-3) kinase/Akt pathway and vascular endothelial cell
growth factor (VEGF) secretion, which may result in decreased tumor cell proliferation
and tumor angiogenesis. The binding of water-insoluble rapamycin to nanoparticle albumin
permits the albumin-mediated endocytosis of rapamycin by tumor cells and endothelial
cells.;
Semantic type(s)