CTCF Pathway - CISMeF

Preferred Label : CTCF Pathway;

NCIt related terms : CTCF: First Multivalent Nuclear Factor;

Alternative definition : BIOCARTA: CTCF is central to signaling pathways in immature B cells elicited by cross-linking the Ig BCR and stimulation with TGF. Both stimuli result in induction of cell cycle arrest and apoptosis. BCR ligation stimulates a transient induction of MYC that leads to high level CTCF expression and feedback suppression of MYC transcription. BCR ligation also activates PTEN opposing PI3K activation of MYC. Pharmacologic inactivation of PI3K or mTOR/FRAP results in suppression of S6K resulting in activation of CTCF and suppression of MYC. CTCF activation induces transcriptional activation of p19ARF, with its downstream consequences, and of p27. Growth arrest is occasioned by co-expression of p21 and p27 and inhibition of MYC. CTCF, is a multivalent DNA-sequence binder whose specificity is mediated by different sets of zinc finger (ZF) proteins. (This definition may be outdated - see the DesignNote.);

NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA Definition might be outdated or inaccurate. Please see the Terms and Conditions for Use at http://www.biocarta.com/.;

Biocarta ID : h_ctcfPathway;

Details

Origin ID

C39040;

UMLS CUI

C1511458;

Semantic type(s)
- Molecular Function [UMLS semantic type]
has_gene_product_element
- B-Cell Antigen Receptor Complex-Associated Protein Alpha Chain [NCIt concept]
- B-Cell Antigen Receptor Complex-Associated Protein Beta Chain [NCIt concept]
- Cellular Tumor Antigen p53 [NCIt concept]
- Cyclin-Dependent Kinase Inhibitor 1B [NCIt concept]
- Cyclin-Dependent Kinase Inhibitor 2A [NCIt concept]
- E3 Ubiquitin-Protein Ligase MDM2 [NCIt concept]
- Mothers Against Decapentaplegic Homolog 1 [NCIt concept]
- Mothers Against Decapentaplegic Homolog 4 [NCIt concept]
- Myc Proto-Oncogene Protein [NCIt concept]
- Phosphatidylinositol 3,4,5-Trisphosphate 3-Phosphatase and Dual-Specificity Protein Phosphatase PTEN [NCIt concept]
- Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha Isoform [NCIt concept]
- Phosphatidylinositol 4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma Isoform [NCIt concept]
- Serine/Threonine-Protein Kinase mTOR [NCIt concept]
- Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit B'' Subunit Beta [NCIt concept]
- TGF-Beta Receptor Type-1 [NCIt concept]
- TGF-Beta Receptor Type-2 [NCIt concept]
- Transcriptional Repressor CTCF [NCIt concept]
- Transforming Growth Factor Beta Receptor Type 3 [NCIt concept]
- Transforming Growth Factor Beta-1 [NCIt concept]
- Tumor Suppressor ARF [NCIt concept]
pathway_has_gene_element
- CD79A wt Allele [NCIt concept]
- CD79B wt Allele [NCIt concept]
- CDKN1B wt Allele [NCIt concept]
- CDKN2A wt Allele [NCIt concept]
- CTCF wt Allele [NCIt concept]
- MDM2 wt Allele [NCIt concept]
- MTOR wt Allele [NCIt concept]
- MYC wt Allele [NCIt concept]
- PIK3CA wt Allele [NCIt concept]
- PIK3CG wt Allele [NCIt concept]
- PIK3R1 wt Allele [NCIt concept]
- PPP2R3B wt Allele [NCIt concept]
- PTEN wt Allele [NCIt concept]
- SMAD1 wt Allele [NCIt concept]
- SMAD4 wt Allele [NCIt concept]
- TGFB1 wt Allele [NCIt concept]
- TGFBR1 wt Allele [NCIt concept]
- TGFBR2 wt Allele [NCIt concept]
- TGFBR3 wt Allele [NCIt concept]
- TP53 wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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