NCIt synonyms : TEP1; Phosphatase and Tensin Homolog (Mutated in Multiple Advanced Cancers 1) Gene; PTEN1; BZS; MMAC1; CWS1; MHAM; Phosphatase and Tensin Homolog wt Allele; Mutated in Multiple Advanced Cancers 1 Gene; Phosphatase and Tensin Homolog Deleted on Chromosome 10 Gene; DEC; GLM2;
NCIt definition : Human PTEN wild type allele is located in the vicinity of 10q23.3 and is approximately
109 kb in length. This allele, which encodes phosphatidylinositol 3,4,5-trisphosphate
3-phosphatase and dual-specificity protein phosphatase PTEN protein, plays a role
in multiple signal transduction pathways. The wild-type allele influences cellular
proliferation, survival, adhesion, migration and cell cycle progression through the
modulation of the phosphorylation state of both phosphoinositides and focal adhesion
kinase. Mutated forms of the gene are found in a large number of cancers.;