Preferred Label : mTOR Signaling Pathway BioCarta;
NCIt related terms : mTOR Signaling Pathway; mTOR Signaling Pathwayc;
NCIt definition : A signal transduction pathway described by the BioCarta database, where exposure of
cells to nutrients, growth factors and other mitogens activate signaling through binding
to various cell surface receptors and ultimately lead to the activation of serine/threonine-protein
kinase mTOR. This pathway plays a role in transcriptional regulation of a number of
genes involved in cellular growth and survival.;
Alternative definition : BIOCARTA: mTOR (mammalian target of rapamycin) appears to play a central role in signaling
caused by nutrients and mitogens such as growth factors to regulate translation. The
drug rapamycin acts on mammalian cells through the mTOR protein kinase, also known
as FRAP. When bound to the immunophilin binding protein FKBP12, rapamycin inhibits
mTOR kinase activity and has immunosuppressant activity. Rapamycin and the mTOR inhibitor
CCI-779 are being tested as anti-cancer agents, acting to block mitogenic signaling.
Recently, mTOR was also found to act as an ATP sensor to regulate cell growth. Upstream
activation of PI 3 kinase activity that leads to oncogenic transformation can be blocked
by inhibition of mTOR by rapamycin. Growth factor receptors first stimulate PI 3 kinase,
and through inositol phosphates activate PDK-1 and AKT (protein kinase B). AKT phosphorylates
mTOR. The phosphorylation of p70S6K and 4EBP by mTOR and the phosphorylation downstream
of RPS6 and EIF-4B stimulate translational initiation and contribute to cell growth.
(This definition may be outdated - see the DesignNote.);
NCIt note : The BIOCARTA Definition (ALT_DEFINITION) for this pathway concept was provided by
BioCarta. This property was not created by, nor is it maintained by the NCI Thesaurus
staff. Additionally, BioCarta is no longer updating its pathway data; thus, the BIOCARTA
Definition might be outdated or inaccurate. Please see the Terms and Conditions for
Use at http://www.biocarta.com/.;
Biocarta ID : h_mTORPathway;
Origin ID : C39159;
UMLS CUI : C1515673;
Semantic type(s)
- concept_is_in_subset
- has_gene_product_element
- pathway_has_gene_element
