Negative Regulation of G1 Phase

Preferred Label : Negative Regulation of G1 Phase;

NCIt synonyms : G1 Block; G1 Arrest;

NCIt definition : G1 Arrest consists of cellular biochemical mechanisms, responsive to diverse governing conditions (DNA damage, contact inhibition, growth factors, etc.), that control cellular progress through the G1 phase of the cell cycle. G1 progress is controlled by de/phosphorylated cyclin/CDK complexes. During G1, cycD/CDK phosphorylation of Rb/HDAC repressor permits E2F/DP1 transcription of genes that promote the G1/S switch and DNA replication. p53 induces p21 inhibition of cycD/CDK; Mdm2 inhibits p53/p21. TGF-b induces p15 inhibition of cycD/CDK. cAMP induces p27 inhibition of cycD/CDK. GSK3b induction of cycD degradation, and INK4, Kip, and Cdc25A regulate cycD/CDK activity.;

Details

Origin ID

C19816;

UMLS CUI

C1517342;

Semantic type(s)
- Molecular Function [UMLS semantic type]
biological_process_has_associated_location
- Cell [NCIt concept]
biological_process_has_initiator_chemical_or_drug
- Mitogen [NCIt concept]
biological_process_has_initiator_process
- Intercellular Communication Process [NCIt concept]
biological_process_involves_gene_product
- Cyclin-Dependent Kinase Inhibitor 1 [NCIt concept]
- Cyclin-Dependent Kinase Inhibitor 2A [NCIt concept]
- Phosphatidylinositol 3,4,5-Trisphosphate 3-Phosphatase and Dual-Specificity Protein Phosphatase PTEN [NCIt concept]
- Serine/Threonine-Protein Kinase Chk2 [NCIt concept]
biological_process_is_part_of_process
- Cell Cycle Process [NCIt concept]
- Cell Proliferation [NCIt concept]
- G1 Phase Process [NCIt concept]
is_physiologic_effect_of_chemical_or_drug
- Alvocidib [NCIt concept]
- Alvocidib Hydrochloride [NCIt concept]
- CDK Inhibitor R547 [NCIt concept]
- Palbociclib [NCIt concept]
- Palbociclib Isethionate [NCIt concept]
- Perillyl Alcohol [NCIt concept]
- Seliciclib [NCIt concept]
- Temsirolimus [NCIt concept]
process_involves_gene
- CDKN1A Gene [NCIt concept]
- CDKN1A wt Allele [NCIt concept]
- CDKN2A Gene [NCIt concept]
- CDKN2A wt Allele [NCIt concept]
- CHEK2 Gene [NCIt concept]
- CHEK2 wt Allele [NCIt concept]
- PTEN Gene [NCIt concept]
- PTEN wt Allele [NCIt concept]

Keyword's position in hierarchy(ies) :

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