Temsirolimus - CISMeF

Preferred Label : Temsirolimus;

NCIt synonyms : Rapamycin Analog CCI-779; Rapamycin Analog; Cell Cycle Inhibitor 779; CCI-779 Rapamycin Analog; 42-(3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoate)rapamycin;

NCIt related terms : Torisel; CCI-779;

NCIt definition : An ester analog of rapamycin. Temsirolimus binds to and inhibits the mammalian target of rapamycin (mTOR), resulting in decreased expression of mRNAs necessary for cell cycle progression and arresting cells in the G1 phase of the cell cycle. mTOR is a serine/threonine kinase which plays a role in the PI3K/AKT pathway that is upregulated in some tumors.;

Alternative definition : NCI-GLOSS: A drug used to treat advanced renal cell carcinoma (a type of kidney cancer). It is also being studied in the treatment of other types of cancer. Temsirolimus blocks a protein involved in cell division, and may kill cancer cells. It is a type of rapamycin analog and a type of serine/threonine kinase inhibitor.;

UNII : 624KN6GM2T;

InChIKey : CBPNZQVSJQDFBE-FUXHJELOSA-N;

CAS number : 162635-04-3;

Drug name : Torisel;

Molecule name : CCI-779; CCI 779;

Chemical formula : C56H87NO16;

NSC code : 683864;

Codes from synonyms : CDR0000046195; 50522; CDR0000554353; CDR0000434624; 485;

Détails

Origin ID

C1844;

UMLS CUI

C1707080;

Automatic exact mappings (from CISMeF team)
- temsirolimus [ATC Code]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_gene_product
- Serine/Threonine-Protein Kinase mTOR [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Enzyme Inhibition [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Negative Regulation of G1 Phase [NCIt concept]
- RNA Transcription Inhibition [NCIt concept]
- Signal Transduction Inhibition [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Serine/Threonine-Protein Kinase mTOR [NCIt concept]
is_component_of_chemotherapy_regimen
- CCI-779/Interferon Alfa [NCIt concept]
- CCI-779/Letrozole [NCIt concept]
- Cyclophosphamide/Temsirolimus/Vinorelbine Regimen [NCIt concept]
- Temsirolimus Regimen [NCIt concept]

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