Preferred Label : Temsirolimus;

NCIt synonyms : Rapamycin Analog CCI-779; Rapamycin Analog; Cell Cycle Inhibitor 779; CCI-779 Rapamycin Analog; 42-(3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoate)rapamycin;

NCIt related terms : Torisel; CCI-779;

NCIt definition : An ester analog of rapamycin. Temsirolimus binds to and inhibits the mammalian target of rapamycin (mTOR), resulting in decreased expression of mRNAs necessary for cell cycle progression and arresting cells in the G1 phase of the cell cycle. mTOR is a serine/threonine kinase which plays a role in the PI3K/AKT pathway that is upregulated in some tumors.;

Alternative definition : NCI-GLOSS: A drug used to treat advanced renal cell carcinoma (a type of kidney cancer). It is also being studied in the treatment of other types of cancer. Temsirolimus blocks a protein involved in cell division, and may kill cancer cells. It is a type of rapamycin analog and a type of serine/threonine kinase inhibitor.;

UNII : 624KN6GM2T;

InChIKey : CBPNZQVSJQDFBE-FUXHJELOSA-N;

CAS number : 162635-04-3;

Drug name : Torisel;

Molecule name : CCI-779; CCI 779;

Chemical formula : C56H87NO16;

NSC code : 683864;

Codes from synonyms : CDR0000046195; 50522; CDR0000554353; CDR0000434624; 485;

Details


Keyword's position in hierarchy(ies) : arborescence

Main resources

You can consult :


https://pgtmsite.files.wordpress.com/2024/01/temsirolimus_es_20080612.pdf
2008
Canada
drug information
temsirolimus
temsirolimus
Temsirolimus

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09/07/2025


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